Tumoroids yield good research models for cancer research and screening of anticancer therapies 

In the study of cancer, tumoroids (tumor-like organoids) represent a promising tool for cost-effective research and screening of anticancer therapies.

Tumoroids are miniaturized and simplified versions of tumors that can replicate and mimic human tumor microenvironments. Accordingly, tumoroid models can be used to perform in-depth investigations of the immune response in cancer progression and assess the impact of different pharmaceutical candidates on the immune reply.

Tumoroids – like other types of organoids (i.e. miniature 3D tissue cultures) – can be grown on scaffolds that offer an environment which allows cells to follow their own genetic instructions to self-organize and form 3D structures that resemble mini-organs.  

Such an optimal environment for cell development and migration is offered by three-dimensional cell growth support structures. These structures allow researchers to 3D culture tiny versions of different tissues, such as organs, using human cells.  

 

Tumoroid formation using bone scaffolds

Bone marrow is a common metastasis site of cancer. That is, cancerous tumors which have arisen in other body parts, such as in breast or prostate cancer, often spread to the bones if the cancer reaches stage IV (the metastasis phase), causing secondary bone cancer. Therefore, it is important to understand how bone tumors develop and destroy bone. Today, this may be done by growing tumoroids on bone scaffolds.  

Cell growth support structures like P3D Scaffolds can be used to culture human tissue and cancer cells on structures that resemble native human bone. The scaffolds accurately mimic the bone environment found in the human body, and thereby secure that cells develop and migrate on the scaffold like they would inside the body.

By adding cancer cells onto the bone-like structures, you can thus grow a tumor replica on a lifelike bone environment. This model can then be used to study bone cancer progression and perform accurate assessments of chemotherapies and novel anticancer drugs, and predictions of patient outcomes. 

In general, animal models and 2D human cell lines have little similarity to human tissue. On the other hand, as the P3D Scaffolds imitate human bone tissue, they yield reliable research models to understand the dynamic in vivo interactions of the cancer. Also, in screening of anticancer therapies, the tumoroid models enable a realistic testing that is thus more likely to yield results when subsequently translated. Thus, while animal models and traditional 2D human cell lines are not always reliable ways to predict how cancer or pharmaceutical treatments will affect humans, disease modeling and drug screening against human organs or tumors grown on scaffolds offer very promising alternative methods.

 

Creating a bone cancer model with P3D Scaffolds

When loaded with cancer cells, the bone scaffolds mimic the histoarchitecture of the primary bone cancer, the genetic landscape of the tumor, and the interplay between the tumor and the host environment. A good disease model is thereby created. Once a tumoroid line is established, you can use this line to test several anticancer pharmaceuticals. According to the response to these pharmaceuticals, you can move on to in vivo animal trials for further testing.

 

Tumoroids in future cancer research

While researchers and the pharmaceutical industry have relied on animal models and 2D human cell lines to secure the developments in cancer research up until this day, the cultivation of tumoroids is now recognized to represent a very promising tool for cost-effective research. With the use of 3D cultured human cells rather than animal models, new therapies may be developed more effectively and in a shorter time frame.

 

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