Particle3D is now offering uniquely lifelike bone environments

Bring natural bone environments to the lab

Enhance your research with:

  • Porous β-TCP bone-like 3D structure
  • Directly translate your research from in vitro to in vivo
  • Realistic setting for testing of therapies and disease mechanisms

 

A Unique Bone-like 3D Structure

Particle3D is now providing uniquely lifelike bone environments wherein disease mechanisms can be studied and new treatments can be tested. The P3D Scaffolds which may be used both in vitro and in in vivo animal models are a fine combination of natural bone materials and a physical shape that precisely mimics the body’s bone environment.

The 3D bone model’s internal porosities, enabled via a patented 3D printing technology, ensures that the surface area of the scaffold is maximized. This secures more realistic testing when drug perfusion is uneven and where bacteria and cancer cells may hide in pores. The unique structures found in the new bone models are difficult to create with traditional ceramic manufacturing techniques and even many 3D printing methods.

 

Directly Translate Your Research From In Vitro to In Vivo

The P3D Scaffolds can be used both in vitro and in vivo to bridge the gap between the lab and animal trial research. This allows for better extrapolations between laboratory research and animal trials, thereby securing that the conclusions derived from in vitro experiments accurately account for the events that occur in vivo.

 

Applications of the P3D Bone Scaffold

Accurate and effective bone research is of great importance to millions of people worldwide, including patients with congenital bone defects and sufferers of diseases like cancer and osteoporosis.
Studies and tests in which the new bone models are used are already well under way. Many different cells may be grown on the 3D printed structures. Particle3D has succesfully grown the following cells on the structures:
 
  • Stem cells including human mesenchymal stem cells, these may be used for studying bone development.
  • Cancer cells including oral carcinoma and lung cancer cells, these may  be used to study cancer invasion and metastasis in bones, a frequent site of cancer metastasis and treatment of bone tumors using therapeutics.
  • Pathogenic bacteria  including staphylococcus aureus, these may be used to study osteomyelitis, surgical site infections and implant biofilms and prevention and treatment of these conditions using pharmaceutics.
  • Environmental microorganisms including bacteria and fungi, these may be used to study the interaction between environmental microorganisms and inorganic 3D structures that mimic environmental structures like soil, rocks, sediment and building materials.

Discover our new webpages to learn more about the P3D Scaffolds and download our flyer.

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