Promising results: P3D Bone ― A natural and strong bone implant
Good preclinical proof from laboratory testing, cell culture and five separate animal trials (three in mice and two in pigs) shows that the P3D Bone implants perform as well as predicted.
The results demonstrate that the P3D Bone implants:
- Are mechanically strong
- Are free from contaminants
- Support a rapid formation of new vascularized bone
- Integrate with neighboring bone in vivo
The two pig trials were conducted in order to test the implant material in an animal close to human size. The first trial involved six pigs, each of which received a mandibular resection in the body of the jaw beneath the teeth, and a P3D Bone was 3D printed for each pig. In the second pig trial, eight pigs received surgically created voids on each side of the angle of the mandible. Here, all eight pigs received a P3D Bone, and half received either a predicate competitor product or a negative control (unfilled void).
Drug releasing bone implants
Particle3D’s laboratory testing has also shown that pharmaceuticals — for instance antibiotics, chemotherapy or growth factors — can be released from implants to kill bacteria or cancer cells, or stimulate faster bone growth, respectively, in the vicinity of the implants.
Tests have shown that the resorption speed and drug release rate can be controlled by varying the fatty acid tail length. This allows for a local, long-term and controlled release of one or more additives from the bone implant.
If you are interested in learning more, these results have been published in the peer-reviewed paper Composites of fatty acids and ceramic powders are versatile biomaterials for personalized implants and controlled release of pharmaceuticals by Martin Bonde Jensen et al. (Bioprinting, 2018).